Speed of onset of bronchodilator response to salbutamol inhaled via different devices in asthmatics: a bioassay based on functional antagonism

F Lavorini, P Geri, L Mariani, C Marmai… - British journal of …, 2006 - Wiley Online Library
… a phenomenon called functional antagonism [17]. With this in mind, we have hypothesized
that a bioassay based on a strong functional antagonism between MCh and salbutamol might …

Agreement between two methods for assessing bioequivalence of inhaled salbutamol

F Lavorini, P Geri, G Camiciottoli, M Pistolesi… - Pulmonary …, 2008 - Elsevier
… We evaluated agreement between the Finney bioassay and … the Diskus in lung delivery of
salbutamol in asthma patients. … clinical bioassay based upon a strong functional antagonism

[图书][B] Evaluation of airway pharmacodynamic and pharmacokinetic properties of bronchoconstrictor and bronchodilator drugs in normal human subjects

NAGM Hassan - 1993 - search.proquest.com
salbutamol is needed for the same degree of antagonism ie … to MeCh inhaled 3 different
formulations of salbutamol; Aerolin … of asthma or atopy, of viral infection within the previous two

[图书][B] Studies of the Bronchodilator Action of the Long Acting β2-Agonist (Salmeterol) in Normal Human Subjects

NAA Zug - 1997 - search.proquest.com
… of methods based on effectiveness, a bioassay has been … did not antagonize salbutamol,
so no functional consequence … of muscarinic antagonists on histamine inhaled in asthmatics is …

Population pharmacodynamic model of bronchodilator response to inhaled albuterol in children and adults with asthma

K Blake, R Madabushi, H Derendorf, J Lima - Chest, 2008 - Elsevier
… the inhaler to release one dose (90 μg) of albuterol into the … available to the patient from the
devices, we chose to use the … presence of endogenous functional antagonists acting at the β …

[HTML][HTML] Spacers and valved holding chambers—the risk of switching to different chambers

F Lavorini, C Barreto, JFM van Boven, W Carroll… - The Journal of Allergy …, 2020 - Elsevier
between inhaler activation and inhalation led to a greater likelihood of uncontrolled asthma
symptoms and a higher rate of … of bronchodilators delivered by virtually any inhalation device

Targeting drugs to the airways: the role of spacer devices

F Lavorini, GA Fontana - Expert opinion on drug delivery, 2009 - Taylor & Francis
… large bronchodilator doses in patients with severe acute asthmaresponse between spacers
and other inhalation devices, … by either the salbutamol dose or inhalation devices, possibly …

[HTML][HTML] New developments in inhaler devices within pharmaceutical companies: a systematic review of the impact on clinical outcomes and patient preferences

V Ninane, J Vandevoorde, D Cataldo, E Derom… - Respiratory …, 2015 - Elsevier
… or asthma that studied the in-company evolution of inhaler … the bronchodilator efficacy of
indacaterol delivered via the … powder inhaler with two blister strips from which inhalation powder …

Influence of ambulatory inhaled treatment with different devices on the duration of acute asthma findings in children

O Yilmaz, A Sogut, U Kose, O Sakinci… - Journal of Asthma, 2009 - Taylor & Francis
… compare the efficacy of inhaled bronchodilator treatment with a … visit rate after admission
while we assessed duration of acute … that compared salbutamol via metered dose inhaler via

[HTML][HTML] The challenge of delivering therapeutic aerosols to asthma patients

F Lavorini - International Scholarly Research Notices, 2013 - hindawi.com
… trial clinical effects of salbutamol inhaled through pMDI with a … inhaled bronchodilators and
corticosteroids will remain the cornerstone of asthma therapy, development of inhaler devices